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About Willem Einthoven, The Einthoven Lectures and the Einthoven Foundation


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Willem Einthoven
The Einthoven Foundation
The Einthoven Lectures and The Einthoven Award


Willem Einthoven (1860-1927)

Willem Einthoven had a long career as professor at Leiden University, from 1886 until his death in 1927.

He was a physiologist with 'strong clinical interests. To Einthoven the ultimate goal of physiology was to understand disease and to benefit patients. His main scientific interests were those of a physicist and naturally his most important contributions were related to the introduction of physical methods and concepts that could be relevant for clinical medicine. At the same time he clearly realized that the potential clinical benefit of research could only be determined after a period of study and experimentation; in 1906 he wrote a paper entitled "Het tele-cardiogram" (The tele-cardiogram) in which he stated: "We should first endeavor to better understand the working of the heart in all its details, and the cause of a large variety of abnormalities. This will enable us, in a possibly still-distant future and based upon a clear insight and improved knowledge, to give relief to the suffering of our patients." These memorable words have lost nothing of their meaning today and indeed merit serious consideration in view of the increasing pressure to produce early results in research. In the first phase of his research career Einthoven probed into various subjects in the fields of vision and respiration but later he restricted himself almost entirely to electrical phenomena in physiology, in particular those related to the heart. To register electrical currents of the heart he started by using the "Lippmann electrometer" as Waller had done before him. Despite Einthoven's improvements, this instrument failed to satisfy his high standards for accuracy so he soon felt compelled to design a new instrument, the string galvanometer. He achieved such perfection that many modern electrocardiographs, incorporating the latest technological developments in electronics, do not attain equally reliable and undistorted electrocardiographic recordings. Einthoven could not have done this without his characteristic unbounded capacity for concentration on the problems he was confronted with and an almost prophetic insight into the future clinical significance of the electrocardiogram. Today, the electrocardiogram having evolved into the most widely applied diagnostic tool in patients with diseases of the heart, it is difficult to realize that Einthoven, as he stated himself, still had to prove that diseases of the heart would lead to abnormalities recognizable in the electrocardiogram. In addition to setting the groundwork of this field by constructing the first instrument capable of accurate recording he developed a system of standardization which continues to be followed all over the world. The significance of this for the development of diagnostic electrocardiography can hardly be overestimated.

Einthoven's contributions to the field were recognized in 1924 when he received the Nobel Prize. lt is characteristic of his modesty that accepting the prize he pointed out that the development of electrocardiography had only been made possible by concerted efforts of many workers in this field, among whom he especially mentioned his British friend, Thomas Lewis.

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THE EINTHOVEN FOUNDATION

The Einthoven Foundation was established in 1979. The board of the Einthoven Foundation and its international advisory board now make proposals for potential recipients of the Einthoven Awards. One of the Major activities of the Einthoven Foundation is the organization of congresses and seminars in which recent developments in cardiology, cardiovascular surgery, and related areas are placed in historical perspective. The Einthoven Lectures are generally part of those meetings but on special occasions the lectures are held separately. Programs are planned to stimulate young investigators who perform original clinical and fundamental research related to the heart and blood vessels. The Einthoven Foundation also encourages the publication of scientific or otherwise enlightening material that may, in a broad sense, serve the preservation of the history of developments in the field of cardiology.

 

HOW TO SUPPORT THE EINTHOVEN FOUNDATION?

The Einthoven Foundation is a non-profit organization which is entirely dependent on donations, legacies, and other gifts. An annual donation of a minimum of Dfl 500,- gives the donor the status of “Friend” of the Einthoven Foundation which includes free access to the Einthoven lectures and some of the other activities organized by the Einthoven Foundation. Donations of more than Dfl 5000,- entitle the Donor to the same privileges in a lifelong capacity and official recognition in the Register of Contributors.

 

Correspondence:

Einthoven Foundation

M. Bootsma, MD, PhD, Secretary
Department of Cardiology
Leiden University Medical Center
P.O. Box 9600, 2300 RC Leiden
The Netherlands

Bank account: 598.28.6195 (Stichting Einthoven, Leiden, The Netherlands)

Email: info@einthoven.nl

 

Board of the Einthoven Foundation

M.J. Schalij, Chairman
M. Bootsma, Secretary
D.E. Atsma, Treasurer

A.C. Gittenberger-de Groot
H.A. Huysmans
M.J. Janse
R. Jonkers
R.F. Visser
E.E. van der Wall

Advisory board of the Einthoven Foundation

G.H. Bieger, Baltimore, USA
H.E.D.J. ter Keurs, Calgary, Canada
E.G. Nabel, USA
J. Schaper, Bad Nauheim, Germany
P.J. Schwartz, Milan, Italy
H.J.J. Wellens, Utrecht, The Netherlands

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THE EINTHOVEN LECTURES AND THE EINTHOVEN AWARD

To commemorate its Nobel Prize Laureate, in 1956 the University of Leiden established the Einthoven Lecture and Einthoven Award. lt was decided to organize this event biennially and to present the Einthoven Award to a physician of international renown who had made outstanding contributions to the field of cardiology, including fundamental as well as clinical aspects. The first speaker was Dr Paul Dudley White, a recognized pioneer in clinical cardiology and a gifted teacher, who was to be followed by many other scientists and clinicians of equal esteem (see below). Traditionally the award is presented by the Rector of the University in a typical academic setting and in the presence of members of the Einthoven family.

 

THE EINTHOVEN LECTURES

Year

Speaker

Title

1956 P.D. White Personal observations on the evolution of cardio-vascular surgery.
1958 A.  Cournand Pulmonary circulation. Historical background and present status of knowledge in man.
1962 L.N. Katz Recent concepts on the perforrnance of the heart.
1964 H.C. Burger Het begrip “arbeid" in natuurkunde, fysiologie en geneeskunde (The concept of labour in physics, physiology and medicine)
1967 H.B. Burchell Mitral competence and incompetence.
1968 D. Durrer Woord en wederwoord (Word and repartee)
1970 E. Braunwald The control of the oxygen consumption of the heart.
1972 W.B. Kannel The natural history of myocardial infarction: The Framingham Study. 
1974 H.V. Pipberger Computer analysis of the electrocardiogram
1977 H.A. Snellen Brief review of Einthoven's publications
1979 A.C. Guyton Historical and modern developments of cardiovascular control concepts. 
1981 J.T. Shepherd Regulation of blood pressure
1983 P.F. Cranefield Past and future aspects of arrhythmias
1985 J.W. Kirklin Is progress still being made in the surgical treatment of valvular heart disease?
1987 D. Steinberg Plasma lipoproteins and the pathogenesis of atherosclerosis
1989 A.T. Winfree Rate, rhythm and fibrillation.
1990 H.J.J. Wellens Electrical current in the diagnosis and treatment of cardiac diseases.
1991 P. Coumel Modern Cardiology: From treatment to diagnosis ?
1993 T.N. James Willem Einthoven Redivivus: Exemplar of World Cardiology. With added comments upon apoptosis and electrocardiography
1995 R. Favaloro Past and present controversies in coronary artery surgery
1997 E.G. Nabel Gene therapy and cardiovascular disease
1999 K. Schwartz Hypertrophy: clinical relevance of genotype
2002 M.R. Rosen The ECG 100 years later: electrical insights into molecular messages
2004 P. Carmeliet Genetics in zebra fish, tadpoles, mice and humans to unravel the molecular basis of vessel deveiopment
2005 S. Rahimtoola Cardiovascular disease in women: Time for women to take charge
2006 H. Drexler Stem cell therapy of patients with endstage heart failure
2007 P.W.J.C. Serruys Future of interventional cardiology
2008 A.N. DeMaria How to translate scientific literature into clinical practice: from JACC to bedside
2009 J. Narula Noninvasive imaging of the vulnerable plaque