Synopsis (1)
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Rationale
Patients with pre-existing heart failure seem to develop complications related to SIRS more often after cardiac surgery than non-heart failure patients. Those with preexisting heart failure show more often a marked temporary reduction in the post-operative pump function, have a higher release of systemic pro-inflammatory cytokines and experience a prolonged stay in ICU due to post-operative complications. These observations suggest attribution of MIRI and SIRS to the impaired outcome for heart failure patients. Suppression of the responses initiated by MIRI has been suggested as therapeutic to improve cardiac surgery outcome.
Study Objective
The main objective is to determine if patients with heart failure have a different myocardial ischemia-reperfusion injury (MIRI) and/or systemic inflammatory response (SIRS) than patients without heart failure.
Study Design
A single center observational study.
