Synopsis (3)

Endpoints of the study

This study will test the hypothesis that MIRI is much more pronounced in the previously damaged heart compared to the normal heart, with left ventricular reconstruction surgery showing the most prominent injury. SIRS is related to the extent of MIRI, and can be characterized in heart failure differently than in normal patients. We assess the contribution of oxidative damage, complement, endothelial, thrombocyt and neutrophil activation and inflammation to human MIRI.